The central dogma of molecular biology is an explanation of the flow of genetic information within a biological system. It was first stated by Francis Crick in 1958. The flow of information is unidirectional: information is transferred from nucleotide sequences into the amino acid sequence of proteins, but never from protein back into the sequence of DNA.
The concept of this phenomenon includes: Transcription of DNA to RNA to protein: This dogma forms the backbone of molecular biology and is represented by four major stages.